NAD⁺ (Buffered)
Contents
What is NAD+?
Nicotinamide adenine dinucleotide (NAD⁺) is a vital coenzyme present in every living cell. It plays a central role in cellular energy production, DNA repair, and metabolic regulation. NAD⁺ levels decline with age, a change linked to reduced mitochondrial function and increased cellular stress. Buffered NAD⁺ formulations are designed to improve tolerability and stability during supplementation or intravenous administration.
Why is NAD+ Important?
NAD⁺ is essential for converting nutrients into usable energy. It also serves as a substrate for enzymes involved in DNA repair (PARPs) and longevity pathways (sirtuins). Adequate NAD⁺ levels support metabolic efficiency and cellular resilience.
How Does NAD+ Work?
NAD+ is an energy-carrying molecule that is used as a source of energy for biologic processes, especially those involving oxidation/reduction reactions. NAD+ can be thought of as similar to ATP, which is the more widely-known energy-carrying molecule. ATP acts as a more immediate source of energy, like gasoline for a car. NAD+ is more indirect energy, like the electrical system that enables the engine to run efficiently.
What is NAD+ Used for?
In the research realm, NAD+ can potentially help in the following avenues:
- Age-related metabolic decline
- Neuroprotection and cognitive health
- Cellular energy and fatigue
- DNA repair and stress resistance
Side Effects of NAD+
In research uses, NAD+ is reported to be rarely associated with flushing or nausea if infused too rapidly. Long-term safety data is still evolving.
NAD+ Dosing Protocol (for Research)
NAD+ research protocols call for once weekly administration under the skin of a research subject (subcutaneous).
- 1Dosing protocol: 50 mg twice weekly (no up-titration needed)
Recommended NAD+ Source (for Research)
