Peptide Pharmacology

Sermorelin

Contents

What is Sermorelin?

Sermorelin is a synthetic peptide that mimics growth hormone-releasing hormone (GHRH), stimulating the pituitary gland to produce growth hormone naturally. It was developed as a diagnostic tool and later explored for treating age-related decline in growth hormone levels.

How Does Sermorelin Work?

Sermorelin binds to GHRH receptors on the pituitary gland, triggering pulsatile growth hormone release. This approach preserves the body’s natural feedback systems, unlike direct growth hormone injections.

What is Sermorelin Used for?

Sermorelin research applications relate to its ability to change body composition by reducing visceral fat, which is the fat found around the internal organs, such as the kidneys. Visceral fat is associated with ill health effects, such as cardiovascular disease. Other potential research applications include:

Side Effects of Sermorelin

Side effects in the research setting include injection site reactions, fluid retention, and mild joint discomfort.

Sermorelin Dosing Protocol (for Research)

Research protocols typically include directions for injection under the skin (subcutaneous). An example research protocol is shown below:

Recommended Sermorelin Source (for Research)

References

Losa M, et al. Stimulation of growth hormone secretion with human growth hormone releasing factors (GRF1-44, GRF1-40, GRF1-29) in normal subjects. Klin Wochenschr. 1984 Dec 3;62(23):1140-3. doi: 10.1007/BF01782473.

Yen SS. Clinical applications of gonadotropin-releasing hormone and gonadotropin-releasing hormone analogs. Fertil Steril. 1983 Mar;39:257-66.