TB-500
Contents
What is TB-500?
TB-500 is a peptide comprised of a 7 amino acid fragment the naturally occuring thymosin beta-4. It is thought to have functions in tissue repair and inflammation control by controlling modulating the cell cytoskeleton.
How Does TB-500 Work?
TB-500 is a synthetic fragment of the larger thymosin beta 4 (TB4) peptide, made up of a specific 7 amino acid sequence that is most closely linked to actin interaction.
Because of this connection to actin, a key component of the cytoskeleton, TB-500 helps reorganize the cell’s structural framework, allowing regenerating cells to move into position after tissue damage. Beyond cell movement, TB-500 has also been shown to promote the growth of new blood vessels following injury, which helps deliver nutrients and other materials needed for repair to the damaged area.
Researchers are also exploring TB-500’s potential ability to direct inflammatory cells to clear debris at the site of injury, helping create a cleaner environment that supports the healing process.
What is TB-500 Used for?
Avenues of research interest for TB-500 include:
- Muscle and tendon repair
- Injury recovery
- Wound healing and inflammation control
Side Effects of TB-500
TB-500 has demonstrated low toxicity in animal studies, which is presumed to similarly translate to humans, but human studies are sparse.
TB-500 Dosing Protocol (for Research)
Independent researchers vary in their recommended dosage and frequency for TB-500. However, one possible dosing algorithm is the following:
- 1Weeks 1-4 (treatment phase): 2.5 mg twice weekly
- 2Week 5 and beyond (maintenance phase): 0.25 mg/day
Recommended TB-500 Source (for Research)
