Melanotan II
Contents
What is melanotan II
Melanotan II is a synthetic peptide closely related to Melanotan I, but with broader activity across melanocortin receptors. Initially investigated for its tanning effects, Melanotan II became widely known for its additional influence on appetite suppression and sexual arousal. Unlike afamelanotide, Melanotan II is not an approved medication and is considered an unregulated research compound.
In the research setting, the tanning effect of Melanotan II is critical, as it results in tanning without causing the negative effects of UV light, which is the most important cause of skin cancer.
How Does Melanotan II Work?
Melanotan II activates multiple melanocortin receptors, including MC1R (pigmentation), MC3R, and MC4R (central nervous system regulation of appetite and sexual function). This non-selective receptor activation explains its wide range of effects.
Stimulation of MC1R increases melanin production, leading to darker skin pigmentation. Activation of MC4R in the brain can suppress appetite and trigger sexual arousal, effects that are not present with Melanotan I.
What is Melanotan II Used for?
Potential research applications for Melanotan II include:
- Cosmetic tanning without UV exposure
- Appetite suppression
- Libido enhancement
Side Effects of Melanotan II
Melanotan II dosing protocol
Melanotan II research dosing protocols call for administration under the skin (subcutaneous). While there are no established dosage recommendations, the research dosing protocol commonly discussed is the following.
- 1Weeks 1-2 (loading phase): 0.5 mg/day
- 2Week 3 and beyond (maintenance phase): 0.25 mg/day
Recommended Melanotan II Source
